The Innovative and Novel Computational Impact on Theory and Experiment program is now accepting proposals for high-impact, computationally intensive research campaigns in a broad array of science, engineering, and computer science domains. As part of its mission, INCITE’s open call provides an opportunity for researchers to make transformational advances in science and technology through large allocations of computer time and supporting resources at the Argonne and Oak Ridge Leadership Computing Facility centers, operated by the US Department of Energy Office of Science.